Lake Kerkini is one of, if not the, premier birding site in Greece, as it is situated along the migratory flyway for birds en route to the Aegean Sea, the Balkan region, the Black Sea and beyond. More than 300 bird species, including several globally threatened or endangered species such as the Dalmatian Pelican and the Pygmy Cormorant, 27 reptile species and 12 species of amphibians have been recorded in the area. Around the lake there is the greatest number of water buffalos in Greece.
The area surrounding Lake Kerkini has been declared a National Nature Reserve and is protected by the International RAMSAR Convention. The lake is a paradise for bird watchers and nature photographers.